Semax was developed in Russia during the 1980’s to treat the effects of brain damage and stroke. This compound is listed as an essential drug by the Russian government.
Semax also possesses astounding abilities as a powerful cognitive enhancing substance.
Semax is a synthetic peptide of a naturally occurring substance called adrenocorticotropic hormone. Adrenocorticotropic hormone is secreted by the pituitary gland and stimulates the adrenal cortex.

The adrenal cortex releases hormones that allow you to deal with physical and emotional stress. Semax basically optimizes our adrenal output.
Most people report this peptide as being an overall mood enhancer which promotes an overwhelming sense of positivity.
This neuropeptide increases the release of dopamine and serotonin.

Some people have reported that Semax increases their cognitive ability.  But I would describe this as a superior version of phenibut. Semax greatly reduces feelings of stress and enables your brain to function with optimized clarity.
There are some studies which show Semax repairing the brain cells from a stroke. And it is also being considered a potential agent for the treatment of ADHD and Rett syndrome.

But Semax is also being studied to restore damage done from cocaine abuse. This is because it doesn’t down-regulate dopamine receptors like an amphetamine like adderall.
This down-regulation causes a huge spike in dopamine levels, but then causes the huge dip afterwards. Instead, this peptide actually up-regulates the receptor.

How To Use Semax

The most common forms of this peptide is either in nasal spray or in glass vials for injection purposes.

The optimum way to use this compound is with subcutaneous injections. This form of administration will allow for a more sustained release of the drug in your system. Thus allowing it to be effective at a moderate level for a longer period of time as opposed to the nasal spray.
This peptide commonly comes in a small glass vial. It will likely have a small amount of the raw powder inside of it. The peptide will be inactive until it is reconstituted with bacteriostatic water inside the vial.
This will essentially ‘bring the substance to life’ and make it active. But keep in mind that it will have a limited shelf life and needs to be refrigerated.

Some people even claim to have success with pre-loading insulin syringes with reconstituted peptides. Then freezing them for future use to prevent wasting the active compound. You would then administer Semax in the subcutaneous fat in the stomach area.

Benefits of Semax

• Shown to decrease negative physical and mental stress
• Prevents increased liver enzymes due to stress
• Could help alleviate anxiety and depression.
• Improved restoration of nerve function in patients recovering from a stroke
• Alleviates pain by preventing the breakdown of enkephalins
• Shown to be helpful in the treatment of ADHD
• Improves memory
• Increases and restores the brain’s neurotransmitters
• Protects the nervous system from oxidative damage of poisonous compounds
• Improves circulation

Side Effects

There really isn’t much data available showing negative side effects from using Semax. There was one study that mention pro-oxidizing effects used at insanely high levels. This is odd because there is an abundance of information detailing the antioxidant abilities used at moderate dosages.

The only other thing I could find was some user reports of temporary anxiety when using excessively high doses.
Ultimately, Semax seems quite safe. And I don’t think that Russia would have this listed as a essential medicine if it wasn’t .